Za posledn\u00edch n\u011bkolik let, LED Red Light Therapy v klinick\u00fdch studi\u00edch, aplikace, a z\u00e1kladn\u00ed experiment\u00e1ln\u00ed v\u00fdzkum, zejm\u00e9na u ko\u017en\u00edch onemocn\u011bn\u00ed, artritidy, osteopor\u00f3zy, hojen\u00ed a opravy ran, proti- infekci a imunomodulaci, atd.<\/p>\n
\u00da\u010dinky \u010derven\u00e9ho sv\u011btla \u00fazce souvisej\u00ed s biologick\u00fdmi funkcemi organismu,, proto, \u010derven\u00e9mu sv\u011btlu LED v\u011bnujeme st\u00e1le v\u011bt\u0161\u00ed pozornost p\u0159i aplikaci souvisej\u00edc\u00edch onemocn\u011bn\u00ed a v z\u00e1kladn\u00edm v\u00fdzkumu. D\u00e1le, se budeme zab\u00fdvat biologick\u00fdmi zm\u011bnami vyvolan\u00fdmi \u010derven\u00fdm sv\u011btlem LED a jeho klinick\u00fdmi studiemi..<\/p>\n
LED je sv\u011bteln\u00e1 dioda-emitting diode (Sv\u011bteln\u00e1 dioda<\/a>) zkratka, jedn\u00e1 se o polovodi\u010dovou elektronickou sou\u010d\u00e1stku, kter\u00e1 p\u0159em\u011b\u0148uje elektrickou energii na sv\u011btelnou energii,, kter\u00e1 se prost\u0159ednictv\u00edm komplexu elektron\u016f a d\u011br, p\u0159em\u011bn\u00ed na sv\u011btelnou energii, uvoln\u011bn\u00ed energie k vyza\u0159ov\u00e1n\u00ed sv\u011btla, pat\u0159\u00ed mezi druh um\u011bl\u00e9ho sv\u011bteln\u00e9ho zdroje.<\/p>\n V zem\u011bd\u011blstv\u00ed, se ke zv\u00fd\u0161en\u00ed produktivity rostlin \u010dasto pou\u017e\u00edv\u00e1 LED sv\u011bteln\u00e1 technologie,, nap\u0159\u00edklad LED p\u011bstebn\u00ed sv\u011btla. P\u0159edchoz\u00ed studie uk\u00e1zaly, \u017ee. LED sv\u011bteln\u00e1 terapie m\u00e1 vyu\u017eit\u00ed v protiz\u00e1n\u011btliv\u00e9 l\u00e9\u010db\u011b a l\u00e9\u010db\u011b bolesti.<\/a>, hojen\u00ed ran, modulace neurologick\u00fdch poruch, kontrola novorozeneck\u00e9 hyperbilirubin\u00e9mie, l\u00e9\u010dba kostn\u00edch poruch, a l\u00e9\u010dba benign\u00edch a malign\u00edch n\u00e1dor\u016f fotodynamickou terapi\u00ed.<\/p>\n Terapie \u010derven\u00fdm sv\u011btlem (Red Light Therapy, RLT) je l\u00e9\u010dba, kter\u00e1 vyu\u017e\u00edv\u00e1 \u010derven\u00e9 sv\u011btlo LED s n\u00edzkou intenzitou- k podpo\u0159e zdrav\u00ed a wellness. Terapie \u010derven\u00fdm sv\u011btlem obvykle vyu\u017e\u00edv\u00e1 \u010derven\u00e9 sv\u011btlo o vlnov\u00e9 d\u00e9lce mezi 620 a 660 nanometry(nm), nebo bl\u00edzk\u00e9- infra\u010derven\u00e9 sv\u011btlo mezi 800 a 850 nanometry..<\/p>\n Tyto vlnov\u00e9 d\u00e9lky \u010derven\u00e9ho sv\u011btla nebo infra\u010derven\u00e9ho sv\u011btla v bl\u00edzkosti- pronikaj\u00ed k\u016f\u017e\u00ed a dosahuj\u00ed bun\u011b\u010dn\u00e9, stimulace mitochondri\u00ed v bu\u0148k\u00e1ch, podpory vnitrobun\u011b\u010dn\u00fdch biochemick\u00fdch reakc\u00ed, zv\u00fd\u0161en\u00ed produkce bun\u011b\u010dn\u00e9 energie, zv\u00fd\u0161en\u00ed energetick\u00e9ho metabolismu, a t\u00edm urychlen\u00ed procesu opravy a regenerace tk\u00e1n\u00ed, sn\u00ed\u017een\u00ed z\u00e1n\u011btu, a zm\u00edrn\u011bn\u00ed bolesti, mimo jin\u00e9..<\/p>\n Oza\u0159ov\u00e1n\u00ed lidsk\u00e9 k\u016f\u017ee \u010derven\u00fdm sv\u011btlem m\u016f\u017ee zv\u00fd\u0161it aktivitu katal\u00e1zy v bun\u011b\u010dn\u00fdch mitochondri\u00edch, a zlep\u0161it bun\u011b\u010dn\u00fd metabolismus tak, \u017ee se zv\u00fd\u0161\u00ed rozklad ATP, synt\u00e9za b\u00edlkovin, a obsah glykogenu, co\u017e podporuje bun\u011b\u010dnou synt\u00e9zu..<\/p>\n Infekce a hojen\u00ed poopera\u010dn\u00edch ran- byly v\u017edy p\u0159edm\u011btem z\u00e1jmu chirurg\u016f. N\u011bkter\u00e9 studie prok\u00e1zaly, \u017ee pou\u017eit\u00ed l\u00e9\u010dby LED sv\u011btlem m\u016f\u017ee v\u00fdznamn\u011b zlep\u0161it hojen\u00ed \u0159ez\u016f lidsk\u00e9 k\u016f\u017ee. Trellesova studie uk\u00e1zala, \u017ee po 20 minut\u00e1ch oza\u0159ov\u00e1n\u00ed \u010derven\u00fdm sv\u011btlem LED 630nm v d\u00e1vce 80 mW\/cm2, se hojen\u00ed ran u pacient\u016f v\u00fdznamn\u011b zlep\u0161ilo, a \u00fa\u010dinn\u011b se zv\u00fd\u0161ila i rychlost hojen\u00ed poopera\u010dn\u00edch ran..<\/p>\n Ve Wangov\u011b experiment\u00e1ln\u00ed studii, byly krys\u00ed gingiv\u00e1ln\u00ed fibroblasty oza\u0159ov\u00e1ny 660nm LED \u010derven\u00fdm sv\u011btlem v d\u00e1vce 3.5 mW\/cm2 po ur\u010ditou dobu za \u00fa\u010delem vyhodnocen\u00ed bun\u011b\u010dn\u00e9 aktivity a hojen\u00ed ran in vitro, a v\u00fdsledky uk\u00e1zaly, \u017ee 660nm LED \u010derven\u00e9 sv\u011btlo oza\u0159ovan\u00e9 energi\u00ed 10-20 J\/cm2 sn\u00ed\u017eilo produkci reaktivn\u00edch forem kysl\u00edku, a z\u00e1rove\u0148, podpo\u0159ilo angiogenezi a reorganizaci do\u010dasn\u00e9 matrix,, \u010d\u00edm\u017e urychlilo hojen\u00ed ran u potkan\u016f..<\/p>\n V\u00fdsledky uk\u00e1zaly, \u017ee energie 660nm LED \u010derven\u00e9ho sv\u011btla v rozsahu 10 ~ 20 J\/cm2 sni\u017euje produkci reaktivn\u00edch forem kysl\u00edku a podporuje angiogenezi a reorganizaci do\u010dasn\u00e9 matrix in vivo,, \u010d\u00edm\u017e urychluje hojen\u00ed ran u potkan\u016f..<\/p>\n Oza\u0159ov\u00e1n\u00ed 660nm \u010derven\u00fdm sv\u011btlem LED podporuje n\u00e1r\u016fst kolagenu IV v kostern\u00edm svalu,, co\u017e vede k \u00fa\u010dinn\u011bj\u0161\u00ed oprav\u011b po\u0161kozen\u00e9ho svalu. Kombinace \u010derven\u00e9ho a modr\u00e9ho sv\u011btla LED \u00fa\u010dinn\u011b stimuluje synt\u00e9zu kolagenu a urychluje p\u0159em\u011bnu fibroblast\u016f na myofibroblasty,, co\u017e prokazuje slo\u017een\u00fd regenera\u010dn\u00ed \u00fa\u010dinek..<\/p>\n 660nm \u010derven\u00e9 LED sv\u011btlo se pou\u017e\u00edv\u00e1 tak\u00e9 p\u0159i l\u00e9\u010db\u011b keloid\u016f a dal\u0161\u00edch fibrotick\u00fdch ko\u017en\u00edch onemocn\u011bn\u00ed. Mamalis a Jagdeo zjistili, \u017ee 660nm \u010derven\u00e9 LED sv\u011btlo m\u016f\u017ee inhibovat proliferaci fibroblast\u016f,, co\u017e m\u016f\u017ee potenci\u00e1ln\u011b pomoci p\u0159i l\u00e9\u010db\u011b jizev a dal\u0161\u00edch fibrotick\u00fdch ko\u017en\u00edch onemocn\u011bn\u00ed..<\/p>\n S postupuj\u00edc\u00edm v\u00fdzkumem, klinick\u00fdmi studiemi a aplikacemi LED \u010derven\u00e9 sv\u011btlo p\u0159i hojen\u00ed ran<\/a> a dal\u0161\u00edch oblastech se roz\u0161\u00ed\u0159\u00ed.<\/p>\n LED je n\u00edzko-heat sv\u011bteln\u00fd zdroj,, kter\u00fd m\u00e9n\u011b po\u0161kozuje k\u016f\u017ei a je bezpe\u010dn\u011bj\u0161\u00ed, a \u010derven\u00e9 sv\u011btlo LED je \u00fa\u010dinn\u00e9 p\u0159i onemocn\u011bn\u00edch pigmentace k\u016f\u017ee, jako je melasma, pihy, akn\u00e9, atd. V\u011bdec zkoumal \u00fa\u010dinek \u010derven\u00e9ho sv\u011btla na synt\u00e9zu melaninu a jeho mechanismus oza\u0159ov\u00e1n\u00edm melanomov\u00fdch bun\u011bk (B16F10) 660nm \u010derven\u00fdm sv\u011btlem LED v d\u00e1vce 7.8 J\/cm2..<\/p>\n V\u00fdsledky uk\u00e1zaly, \u017ee 660nm \u010derven\u00e9 sv\u011btlo LED m\u016f\u017ee inhibovat aktivitu tyrozin\u00e1zy indukovanou \u03b1-melanocyty stimuluj\u00edc\u00edm hormonem v bu\u0148k\u00e1ch B16F10,, a t\u00edm inhibovat synt\u00e9zu melaninu..<\/p>\n Bylo tak\u00e9 zji\u0161t\u011bno, \u017ee 660nm \u010derven\u00e9 LED sv\u011btlo vyvol\u00e1v\u00e1 depigmenta\u010dn\u00ed \u00fa\u010dinek t\u00edm, \u017ee vyvol\u00e1v\u00e1 aktivaci extracelul\u00e1rn\u011b regulovan\u00fdch proteinov\u00fdch kin\u00e1z a sni\u017euje expresi transkrip\u010dn\u00edch faktor\u016f spojen\u00fdch s mikroftalmi\u00ed- a protein\u016f tyrozin\u00e1zy..<\/p>\n Fototerapii lze pou\u017e\u00edt jako bezpe\u010dnou alternativn\u00ed l\u00e9\u010dbu z\u00e1n\u011btliv\u00fdch ko\u017en\u00edch onemocn\u011bn\u00ed, jako je akn\u00e9,, a v literatu\u0159e bylo prok\u00e1z\u00e1no, \u017ee vysok\u00e9 d\u00e1vky (>10 J\/cm2 ) modr\u00e9ho a \u010derven\u00e9ho sv\u011btla LED maj\u00ed v\u00fdznamn\u00fd \u00fa\u010dinek na z\u00e1n\u011btliv\u00e9 akn\u00e9. L\u00e9ze akn\u00e9 se zlep\u0161ily i p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch (0.2~1.2J\/cm2) \u010derven\u00e9ho sv\u011btla LED..<\/p>\n Terapie \u010derven\u00fdm sv\u011btlem LED m\u00e1 pozitivn\u00ed regulaci a pozitivn\u00ed \u00fa\u010dinky na diferenciaci osteoblast\u016f a tvorbu kost\u00ed, mnoho syst\u00e9mov\u00fdch a region\u00e1ln\u00edch onemocn\u011bn\u00ed spojen\u00fdch s \u00fabytkem kostn\u00ed hmoty,, jako je osteopor\u00f3za a osteochondr\u00f3za, je zp\u016fsobeno p\u0159edev\u0161\u00edm zv\u00fd\u0161en\u00edm a up-regulac\u00ed aktivity osteoklast\u016f..<\/p>\n Bylo zji\u0161t\u011bno, \u017ee 635nm LED \u010derven\u00e9 sv\u011btlo oza\u0159uj\u00edc\u00ed osteoklasty v d\u00e1vce 2mW\/cm2 po dobu 72 hodin m\u016f\u017ee zp\u016fsobit poruchy aktinu a sn\u00ed\u017eit \u00farove\u0148 exprese gen\u016f (nap\u0159. integrin \u03b23 a c-Src), kter\u00e9 ovliv\u0148uj\u00ed tvorbu aktinov\u00fdch kruh\u016f,, \u010d\u00edm\u017e inhibuj\u00ed kostn\u00ed resorp\u010dn\u00ed osteoklasty,, tak\u017ee vid\u00edme, \u017ee 635nm LED \u010derven\u00e9 sv\u011btlo hraje kl\u00ed\u010dovou roli v regulaci kostn\u00ed remodelace..<\/p>\n Sohn zjistil, \u017ee 635 nm, 5 mW\/cm2 LED \u010derven\u00e9 sv\u011btlo m\u016f\u017ee v\u00fdznamn\u011b sn\u00ed\u017eit aktivitu jadern\u00e9ho faktoru-\u03baB (NF-\u03baB) a intracelul\u00e1rn\u00ed produkci ROS,, co\u017e m\u016f\u017ee sn\u00ed\u017eit- regulaci osteoklastogeneze..<\/p>\n Jin\u00e1 studie uk\u00e1zala, \u017ee oza\u0159ov\u00e1n\u00ed my\u0161\u00ed \u010derven\u00fdm sv\u011btlem LED 630 nm v d\u00e1vce 5 mW\/cm2 podporuje proliferaci prekurzorov\u00fdch bun\u011bk embryon\u00e1ln\u00edch osteoblast\u016f (MC3T3-E1), a po ur\u010dit\u00e9 dob\u011b kultivace bun\u011bk zlep\u0161uje diferenciaci osteoblast\u016f..<\/p>\n Oza\u0159ov\u00e1n\u00ed \u010derven\u00fdm sv\u011btlem LED, proto m\u016f\u017ee b\u00fdt \u00fa\u010dinn\u00fdm n\u00e1strojem prevence \u00fabytku kostn\u00ed hmoty p\u0159i osteopor\u00f3ze a dal\u0161\u00edch kostn\u00edch resorp\u010dn\u00edch onemocn\u011bn\u00edch..<\/p>\n Lok\u00e1ln\u00ed ischemie je b\u011b\u017en\u00e9 onemocn\u011bn\u00ed spojen\u00e9 se sn\u00ed\u017een\u00fdm prokrven\u00edm ur\u010dit\u00fdch org\u00e1n\u016f nebo tk\u00e1n\u00ed, a hlavn\u00edm c\u00edlem jej\u00ed l\u00e9\u010dby je stimulace neovaskularizace c\u00e9v..<\/p>\n Park zkoumal regeneraci c\u00e9v z tukov\u00fdch-kmenov\u00fdch bun\u011bk (ASCs) oza\u0159ov\u00e1n\u00edm ischemick\u00fdch kon\u010detin \u010derven\u00fdm sv\u011btlem LED. Po oz\u00e1\u0159en\u00ed \u010derven\u00fdm sv\u011btlem LED o vlnov\u00e9 d\u00e9lce 650 nm, 50 mW\/cm2, ASCs o\u0161et\u0159en\u00e9 LED-kmenov\u00fdmi bu\u0148kami (ASCs). vykazovaly tvorbu nov\u00fdch c\u00e9v a regeneraci tk\u00e1n\u011b,, co\u017e nazna\u010duje, \u017ee \u010derven\u00e9 sv\u011btlo LED m\u016f\u017ee podpo\u0159it regeneraci c\u00e9v a zv\u00fd\u0161it p\u0159e\u017eit\u00ed ASC a stimulovat sekreci r\u016fstov\u00fdch faktor\u016f v ischemick\u00fdch kon\u010detin\u00e1ch..<\/p>\n Koncem 60. let minul\u00e9ho stolet\u00ed, provedl ma\u010farsk\u00fd l\u00e9ka\u0159 s\u00e9rii test\u016f domn\u011bnek na my\u0161\u00edch, \u017ee lasery zp\u016fsobuj\u00ed rakovinu,, ale testem se zjistilo, \u017ee lasery zlep\u0161uj\u00ed proliferaci chloupk\u016f kolem holen\u00ed my\u0161\u00ed, a poprv\u00e9 navrhl fotobiologickou terapii pro v\u00fdvoj medic\u00edny, aby otev\u0159el novou cestu. LED je skv\u011blou alternativou k laserov\u00e9mu zdroji sv\u011btla, pro r\u016fzn\u00e9 nemoci v \u0161irok\u00e9m spektru aplikac\u00ed..<\/p>\n Na z\u00e1klad\u011b v\u00fd\u0161e uveden\u00e9ho v\u00fdzkumu, Hong provedl velk\u00e9 mno\u017estv\u00ed experiment\u016f,, kter\u00e9 prok\u00e1zaly, \u017ee bu\u0148ky lidsk\u00e9 derm\u00e1ln\u00ed vlasov\u00e9 papily (hDPC) se rychleji mno\u017eily po oz\u00e1\u0159en\u00ed 660nm, 2. 42 mW\/cm2 LED po dobu 70 min..<\/p>\n Dal\u0161\u00ed studie zjistily, \u017ee \u010derven\u00e9 sv\u011btlo LED podporuje proliferaci HD-PC stimulac\u00ed signalizace Wnt \/ \u03b2-cyklin a sign\u00e1ln\u00ed dr\u00e1hy ERK, a testy in vitro na vlasov\u00fdch folikulech lidsk\u00e9 poko\u017eky hlavy uk\u00e1zaly, \u017ee \u010derven\u00e9 sv\u011btlo LED m\u00e1 pozitivn\u00ed vliv na r\u016fst vlas\u016f..<\/p>\n LED Jako velmi slibn\u00fd zdroj studen\u00e9ho sv\u011btla, \u010cerven\u00e9 sv\u011btlo LED hraje aktivn\u00ed roli v pozitivn\u00ed modulaci hojen\u00ed ran, k\u016f\u017ee, \u00falev\u011b od bolesti, metabolick\u00fdch abnormalit, a poruch imunity. Jako zdroj sv\u011btla s fyzik\u00e1ln\u00edm z\u00e1sahem, \u010cerven\u00e9 sv\u011btlo LED m\u016f\u017ee podporovat proliferaci prim\u00e1rn\u00edch bun\u011bk (jako jsou tukov\u00e9- kmenov\u00e9 bu\u0148ky a nervov\u00e9 bu\u0148ky) a hr\u00e1t ur\u010ditou pomocnou roli p\u0159i l\u00e9\u010db\u011b nemoc\u00ed..<\/p>\n V\u00fdzkum a v\u00fdvoj zdravotnick\u00fdch p\u0159\u00edstroj\u016f souvisej\u00edc\u00edch s LED bude d\u016fle\u017eit\u00fdm sm\u011brem budouc\u00edho spojen\u00ed medic\u00edny a optiky, zejm\u00e9na p\u0159enosn\u00fdch, nositeln\u00fdch p\u0159\u00edstroj\u016f. Za\u0159\u00edzen\u00ed pro sv\u011btelnou terapii LED<\/a> bude ur\u010dit\u011b sm\u011b\u0159ovat k budouc\u00edmu pokroku v medic\u00edn\u011b, terapie \u010derven\u00fdm sv\u011btlem LED bude m\u00edt rozs\u00e1hlej\u0161\u00ed slu\u017eby a lidsk\u00e9 zdrav\u00ed.<\/p>","protected":false},"excerpt":{"rendered":" Za posledn\u00edch n\u011bkolik let, LED \u010derven\u00e1 sv\u011bteln\u00e1 terapie v klinick\u00fdch studi\u00edch, aplikace, a z\u00e1kladn\u00ed experiment\u00e1ln\u00ed v\u00fdzkum, zejm\u00e9na u ko\u017en\u00edch onemocn\u011bn\u00ed, artritida, osteopor\u00f3za, hojen\u00ed a opravy ran, proti- infekce a imunomodulace, atd. \u00da\u010dinky \u010derven\u00e9ho sv\u011btla jsou \u00fazce spojeny s biologick\u00fdmi funkcemi organismu, proto, LED \u010derven\u00e9 sv\u011btlo z\u00edsk\u00e1v\u00e1 st\u00e1le v\u00edce...<\/p>","protected":false},"author":1,"featured_media":90399,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-90364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","category-1","description-off"],"acf":[],"_links":{"self":[{"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/posts\/90364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/comments?post=90364"}],"version-history":[{"count":0,"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/posts\/90364\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/media\/90399"}],"wp:attachment":[{"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/media?parent=90364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/categories?post=90364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lighttherapyhome.com\/cs\/wp-json\/wp\/v2\/tags?post=90364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Co je sv\u011bteln\u00e1 terapie LED?<\/h2>\n
Co je terapie \u010derven\u00fdm sv\u011btlem LED?<\/h2>\n
Jak funguje terapie \u010derven\u00fdm sv\u011btlem?<\/h2>\n
1. LED \u010derven\u00e9 sv\u011btlo opravuje po\u0161kozenou k\u016f\u017ei a tk\u00e1\u0148<\/h2>\n
2. LED \u010derven\u00e9 sv\u011btlo pro pigmentaci k\u016f\u017ee<\/h2>\n
3. LED \u010derven\u00e9 sv\u011btlo pro nemoci kost\u00ed a kloub\u016f<\/h2>\n
4. LED \u010derven\u00e9 sv\u011btlo podporuje regeneraci krevn\u00edch c\u00e9v<\/h2>\n
5. LED \u010derven\u00e9 sv\u011btlo podporuje r\u016fst vlas\u016f<\/h2>\n
Souhrn<\/h2>\n